New 2-(pyrazolopyridin-3-yl)pyrimidine derivatives are disclosed; as well as process for their preparation, pharmaceutical compositions comprising them and their use in therapy as inhibitors of Janus Kinases (JAK).本發明揭露一種新穎的2-(吡唑并吡啶-3-基)嘧啶衍生物、以及它們的製備方法、包含它們的藥物組成物和它們作為Janus激酶(JAK)抑制劑在治療中的用途。