New pyridin-2(1H)-one derivatives having the chemical structure of formula (I) are disclosed; as well as process for their preparation, pharmaceutical compositions comprising them and their use in therapy as inhibitors of Janus Kinases (JAK).本發明揭露具有式(I)化學結構之新穎吡啶-2(1H)-酮衍生物;以及其製備方法,包括其之醫藥組合物以及其作為傑納斯激酶(Janus Kinase,JAK)之抑制劑用於療法中的用途。