New pyrazolopyridmiin-2-yl derivatives are disclosed; as well as process for their preparation, pharmaceutical compositions comprising them and their use in therapy as inhibitors of Janus Kinases (JAK).本發明揭露新穎的吡唑并嘧啶-2-基衍生物;以及用於其製備之方法,包含該等衍生物之醫藥組合物,及其在療法中作為Janus激酶(JAK)抑制劑之用途。