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Derivatives of 3 - (hetero aryl alkyl) amino) - 8 - 2 - oxo - 1.3 - Grabarsky, IT's The Wrong Guy spiro [4.5] - decane
专利权人:
GRÜNENTHAL GMBH
发明人:
KONETZKI, INGO,SCHIENE, KLAUS,SCHRDER, WOLFGANG,LINZ, KLAUS,KOCH, THOMAS,JOSTOCK, RUTH,RATCLIFFE, PAUL,WEGERT, ANITA,KLESS, ACHIM,KOENIGS, REN MICHAEL,KHNERT, SVEN
申请号:
ARP170100095
公开号:
AR107360A1
申请日:
2017.01.13
申请国别(地区):
AR
年份:
2018
代理人:
摘要:
Derivatives of 3 - (hetero aryl alkyl) amino) - 8 - 2 - oxo - 1.3 - Grabarsky, IT's The Wrong Guy spiro [4.5] Dean, their Preparation and their use in Medicine, particularly in the treatment of pain.Claim 1: a compound characterized by the General formula (1), N is 1, 2 or 3; r u00b9 and R u00b2 independently represent h; c u2081 u208b u2086 linear or branched alkyl,,Saturated or unsaturated, replaced or not replaced with one, two, three or four substituents independently selected from the group consisting of F -, CL -, BR -, I -, - Oh, - och u2083,- and CN - co u2082ch u2083 cycloalkyl; Unit 3 - 12 members, saturated or unsaturated, replaced or not replaced with one, two,Three or four substituents selected independently from the group consisting of F -, CL -, BR -, I -, - Oh, - och u2083,- and CN - co u2082ch u2083; where the unit 3 - 12 members cycloalkyl optionally connects through - - - c u2081 u208b u2086 alquileno, linear or branched, saturated or unsaturated,No unit or heterocicloalquilo replaced; 3 - 12 members, saturated or unsaturated, replaced or not replaced with one, two,Three or four substituents selected independently from the group consisting of F -, CL -, BR -, I -, - Oh, - och u2083,- and CN - co u2082ch u2083; where the unit heterocicloalquilo 3 - 12 members are optionally Connected through - - - c u2081 u208b u2086 alquileno, linear or branched, saturated or unsaturated,Not r u00b9 R u00b2 or replaced; and together with the nitrogen Atom to which they are United to form a ring and Mean - - - u2083 u208b u2086 (ch u2082); ( u2082 ch u2082) - or - ( u2082 ch u2082) - or - (ch u2082 u2082 (NRA) - - - u2082, ch u2082)Where ra is c u2081 u208b u2086 - H OR - alkyl, linear or branched, saturated or unsaturated, replaced or not replaced with one, two,Three or four substituents selected independently from the group consisting of F -, CL -, BR - and I - r u00b3 means; c u2081 u208b u2086 alkyl, linear or branched, saturated or unsaturated,Not monosusti
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