The University of British Columbia;British Columbia Cancer Agency Branch
发明人:
SADAR, Marianne D.,MAWJI, Nasrin R.,WANG, Jun,ANDERSEN, Raymond J.,WILLIAMS, David E.,LEBLANC, Mike,YAN, Lu-Ping,SADAR MARIANNE D,SADAR, MARIANNE D.,MAWJI NASRIN R,MAWJI, NASRIN R.,WANG JUN,WANG, JUN,ANDERSEN RAYMOND J,ANDERSEN, RAYMOND J.,WILLIAMS DAVID E,WILLIAMS, DAVID E.,LEBLANC MIKE,LEBLANC, MIKE,Yan lu-pin
申请号：
ES09807798
公开号：
ES2593859T3
申请日:
2009.08.24
申请国别(地区):
ES
年份:
2016
代理人:
摘要：
A compound of formula (B): ** Formula ** or a salt thereof, in which: X is N； Cast； R1 is H, OH, J, OJ, SJ or NJJ ', in which J or J' is a linear, branched, cyclic, non-aromatic, or aromatic, saturated or unsaturated, optionally substituted alkyl group of one to ten carbons. wherein the optional substituent is selected from one or more of: oxo, COOH, OH, F, Cl, Br, I, NH2, CN, SH, SO3H and NO2； R2 is H or a linear, branched, or cyclic non-aromatic, saturated or unsaturated, optionally substituted alkyl group in which the optional substituent is selected from one or more of: oxo, COOH, R, OH, OR, F, Cl, Br, I, NH2, NHR, NR2, CN, SH, SR, SO3H, SO3R, SO2R, OSO3R and NO2 and in which R is a linear C1-C10 alkyl, or branched and unsubstituted saturated ； R3 is H, OH, OG, SG, NGG 'or a linear, branched, or cyclic non-aromatic, saturated or unsaturated, optionally substituted alkyl group, in which G and G' are an alkyl group of one 10-carbon linear, branched, or non-aromatic, saturated or unsaturated cyclic and in which the optional substituent is selected from one or more of: oxo, COOH, OH, F, Cl, Br, I, NH2, CN, SH, SO3H and NO2； R4 is H or a linear, branched, saturated, optionally substituted alkyl group of one to four carbons, in which the optional substituent is selected from one or more of: oxo, OH, F, Cl, Br, I and NH2； R5 is H or a linear, branched, or cyclic non-aromatic, saturated or unsaturated, optionally substituted alkyl group in which the optional substituent is selected from one or more of: oxo, COOH, OH, F, Cl, Br, I, NH2, SO3H and NO2； Z is an optionally substituted Bu, Pr, Et or Me, wherein the optional substituent is selected from one or more of: oxo, COOH, OH, F, Cl, Br, I, NH2, SO3H and NO2； --------- is a single link or a double link； and provided that the compound is not: (2S, 5S, 7S, 15S) -disideapirrolidone, ** Formula **Un compuesto de fórmula (B):**Fórmula** o una sal del mismo, en la que: X es N； Y es O； R1 es H, OH, J, OJ, SJ o NJJ', en el que
