BURGDORF, Lars,KUHN, Daniel,ROSS, Tatjana,DEUTSCH, Carl
申请号：
ES13735205
公开号：
ES2618004T3
申请日:
2013.07.10
申请国别(地区):
ES
年份:
2017
代理人:
摘要：
Compounds of the formula I ** Formula ** in which R means H, OH, A or NR4R4 ', R1 means Ar1, Het1, CN, A or -C≡C-Ar1, R2 means Het2, NR3Cic, NR3CR3CON (R3 ) 2, NR3 [C (R3) 2] pCR3 (NH2) CH2OA or NR3 [C (R3) 2] pN (R3) 2, Ar1 means phenyl, which is mono-, di- or trisubstituted by A, ( CH2) nHet3, [C (R3) 2] nOR3, [C (R3) 2] nN (R3) 2, NO2, CN, Hal, COOR3, CON (R3) 2, NR3COA, NR3SO2A, SO2N (R3) 2 and / or S (O) mA, Het1 means 3,6-dihydro-2H-pyranyl, tetrahydropyridinyl, 1,3-dihydro-benzimidazolyl, pyrazolyl, chromanyl, 1,2,3,4-tetrahydro-pyrazolo [1,5- a] pyridinyl, 6,7-dihydro-4H-pyrazolo [5,1-c] [1,4] -oxazinyl, 1,4-dihydro-benzo [d] [1,3] -oxazinyl, 4H-benzo [ 1,4] oxazinyl, benzimidazolyl, pyridyl, pyrimidinyl, imidazolyl, pyrazolyl, furyl, thiazolyl, triazolyl, benzotriazolyl, indolyl, indazolyl, 1,3- or 2,3-dihydro-indolyl, each of which is unsubstituted or mono-, di-, tri- or tetrasubstituted by A, CN, OH, OA, Hal, SO2NH2, (CH2) nNH2, (CH2) nNHA, (CH2) nNA2 and / or>； = O, Het2 means piperidinyl, piperazinyl, pyrrolidinyl, morpholinyl, tetrahydropyranyl, pyrazolyl, indazolyl, azetidinyl or octahydro-benzimidazolyl, each of which is mono-, di- or trisubstituted by Hal, A, (CH2) nNH2, (CH2) nNHA, ( CH2) nNA2, (CH2) nOH and / or (CH2) nOA, Het3 means piperidinyl, piperazinyl, pyrrolidinyl, morpholinyl, imidazolidinyl, pyridyl, pyrimidinyl, imidazolyl, pyrazolyl, furyl, thiazolyl or triazolyl, each of which is unsubstituted or mono- or disubstituted by A and / or>； = O, R3 means H or alkyl having 1, 2, 3 or 4 atoms of C, R4, R4 'each, independently of one another, means H or A, A means unbranched or branched alkyl having 1-10 C atoms, in which case 1-7 H atoms can be replaced by F and / or one or two non-adjacent CH2 groups can be replaced by O and / or NH, or cyclic alkyl having 3-7 C atoms, Cyc means cyclic alkyl having 3-7 C atoms, which may be unsubstituted or mo substituted by NH2, CN, CONH2 or OH, m means 0, 1 or 2, n means 0, 1, 2, 3 or 4, p means 1, 2,
