PROBLEM TO BE SOLVED: To provide an evaluation system for correctly evaluating the hair growth effect of a newly developed hair regeneration technique. A human skin having hair follicles, comprising human epidermal cells and human dermal cells, wherein the human dermal cells include a cell group of non-fetal-derived human dermal papilla that has undergone spheroid formation. Composition for reconstituting tissue, human skin tissue model animal to which it is applied, prepare a spheroid containing human hair papilla cells of non-fetal origin, and mix the spheroid with human epidermal cells and human dermal cells A method for producing the above composition, which comprises culturing the composition, and a method for producing the animal model for human skin tissue, which comprises applying the composition to a non-human mammal animal. [Selection diagram] Figure 1【課題】新規に開発された毛髪再生技術の発毛効果を正しく評価するための評価系の提供。【解決手段】ヒト表皮細胞とヒト真皮細胞とを含み、ここで前記ヒト真皮細胞がスフェロイド形成を経た非胎児由来のヒト毛乳頭の細胞群を含むことを特徴とする、毛包を有するヒト皮膚組織を再構成するための組成物、それが適用されたヒト皮膚組織モデル動物、非胎児由来のヒト毛乳頭細胞を含むスフェロイドを調製し、前記スフェロイドとヒト表皮細胞とヒト真皮細胞とを混合して培養する工程を含む、前記組成物を製造する方法、および、前記組成物を非ヒト哺乳類動物に適用する工程を含む、前記ヒト皮膚組織モデル動物の製造方法。【選択図】図１
