The present invention discloses a patch for transdermal drug delivery and a method of controlling drug release of the same by near-IR. The patch for transdermal drug delivery comprises a substrate, a carrier and drugs. The drugs are encapsulated in the carrier, and the carrier having the drugs is disposed on a surface of the substrate. The carrier is formed of biodegradable polymers, and nano-particles with a photothermal conversion effect are loaded in the carrier. When the carrier is inserted into the skin and the nano-particles in the carrier absorb the near-IR, the near-IR is converted into heat by the nano-particles for melting the carrier and thus releasing the drugs encapsulated in the carrier into the skin. Accordingly, the velocity of releasing the drugs encapsulated in the carrier can be controlled accurately by the near-IR.
