The subject invention provides a drug delivery system comprising at least onecompartment comprising (i) a drug--loadedthermoplastic polymer core layer, (ii) a drug-loaded thermoplastic polymerintermediate layer and (iii) a non-medicated thermoplasticpolymer skin covering the intermediate layer, wherein said core layer isloaded with crystals of a first (pharmaceutically)active compound and said intermediate layer is loaded with crystals of thesecond (pharmaceutically) active compound.
