Regeneron Pharmaceuticals, Inc.;President and Fellows of Harvard College
发明人:
LAI, Ka-Man Venus,GONG, Guochun,FRENDEWEY, David,VALENZUELA, David M,RINN, John
申请号：
DK17152034
公开号：
DK3178928T3
申请日:
2014.08.07
申请国别(地区):
DK
年份:
2020
代理人:
摘要：
Genetically modified non-human animals are provided that exhibit a functional lack of one or more IncRNAs. Methods and compositions for disrupting, deleting, and/or replacing IncRNA-encoding sequences are provided. Genetically modified mice that age prematurely are provided. Also provided are cells, tissues and embryos that are genetically modified to comprise a loss-of-function of one or more IncRNAs.
