Regeneron Pharmaceuticals, Inc.;President and Fellows of Harvard College
发明人:
Ka-Man Venus Lai,Guochun Gong,John Rinn,David Frendewey,David M. Valenzuela
申请号：
US14454464
公开号：
US09554564B2
申请日:
2014.08.07
申请国别(地区):
US
年份:
2017
代理人:
摘要：
Genetically modified non-human animals are provided that exhibit a functional lack of one or more lncRNAs. Methods and compositions for disrupting, deleting, and/or replacing lncRNA-encoding sequences are provided. Genetically modified mice that age prematurely are provided. Also provided are cells, tissues and embryos that are genetically modified to comprise a loss-of-function of one or more lncRNAs.
