PROBLEM TO BE SOLVED: To provide novel antibodies targeting TLR9.SOLUTION: An antibody of the invention recognizes the N-terminus of TLR9, where the N-terminus of TLR9 has: a specific amino acid sequence; an amino acid sequence having deletion, substitution or addition of one or more amino acids in the specific amino acid sequence; and an amino acid sequence having 90% or more identity to the specific amino acid sequence, and the N terminus-recognizing antibody has: an amino acid sequence represented by one of specified sequences; an amino acid sequence having deletion, substitution or addition of one or more amino acids in an amino acid sequence represented by one of the specified sequences; and an amino acid sequence having 90% or more identity to an amino acid sequence represented by any of the specified sequences.SELECTED DRAWING: None【課題】TLR9を標的とする新規な抗体の提供。【解決手段】TLR9のN末端を認識する抗体で、TLR9のN末端が、特定のアミノ酸配列、1又は複数のアミノ酸の欠失、置換又は付加を有するアミノ酸配列;及び特定のアミノ酸配列と90%以上の同一性を有するアミノ酸配列を有し、N末端認識抗体は、複数の特定の配列で表されるアミノ酸配列において、1又は複数のアミノ酸の欠失、置換又は付加を有するアミノ酸配列;及び特定の配列のいずれかで表されるアミノ酸配列と90%以上の同一性を有するアミノ酸配列を有する抗体。【選択図】なし