REGENERON PHARMACEUTICALS, INC.;PRESIDENT AND FELLOWS OF HARVARD COLLEGE
发明人:
LAI, KA-MAN VENUS,GONG, GUOCHUN,RINN, JOHN,FRENDEWEY, DAVID,VALENZUELA, DAVID M.
申请号：
CA2917714
公开号：
CA2917714A1
申请日:
2014.08.07
申请国别(地区):
CA
年份:
2015
代理人:
摘要：
Genetically modified non-human animals are provided that exhibit a functional lack of one or more lncRNAs. Methods and compositions for disrupting, deleting, and/or replacing lncRNA-encoding sequences are provided. Genetically modified mice that age prematurely are provided. Also provided are cells, tissues and embryos that are genetically modified to comprise a loss-of-function of one or more lncRNAs.
