LAI KA MAN VENUS,GONG GUOCHUN,RINN JOHN,FRENDEWEY DAVID,VALENZUELA DAVID M
申请号：
IN201617002360
公开号：
IN201617002360A
申请日:
2016.01.21
申请国别(地区):
IN
年份:
2016
代理人:
摘要：
Genetically modified non human animals are provided that exhibit a functional lack of one or more lncRNAs. Methods and compositions for disrupting deleting and/or replacing lncRNA encoding sequences are provided. Genetically modified mice that age prematurely are provided. Also provided are cells tissues and embryos that are genetically modified to comprise a loss of function of one or more lncRNAs.
