THE PRESENT INVENTION RELATES TO THE USE OF FUJIMYCIN FOR THE TREATMENT OF A DISORDER RELATED TO THE CHRONOLOGICAL AND/OR REPLICATIVE LIFE-SPAN OF A CELL, AND TO METHODS FOR INCREASING THE REPLICATIVE LIFE SPAN OF A CELL SAID METHOD COMPRISING DISRUPTING THE FUNCTION OF A POLYNUCLEOTIDE OR GENE ENCODING A POLYNUCLEOTIDE OR GENE ENCODING A POLYPEPTIDE COMPRISING SEQ ID NO: 1,3 OR 5. FIGURE 4