HADIDA-RUAH, Sara,ANDERSON, Corey,ARUMUGAM, Vijayalaksmi,ASGIAN, Iuliana,BEAR, Brian,TERMIN, Andreas,JOHNSON, James
申请号：
ES14704053
公开号：
ES2626555T3
申请日:
2014.01.29
申请国别(地区):
ES
年份:
2017
代理人:
摘要：
A compound of formula I or I '++ Formula ** or a pharmaceutically acceptable salt thereof, in which, independently for each case: G is ** Formula ** X is a bond or C1-C6 alkyl in which said C1-C6 alkyl is substituted with 0-6 halogen, wherein up to two two non-adjacent CH2 units of said C1-C6 alkyl may be replaced with -O-； Rx is absent, H, or cycloaliphatic C3-C8, in which up to two non-adjacent CH2 units of said cycloaliphatic C3-C8 can be substituted with -O- and said cycloaliphatic C3-C8 is substituted with 0-3 halogen selected substituents and C1-C4 alkyl； R1 is H, halogen, CN, or C1-C6 alkyl in which said C1-C6 alkyl is substituted with 0-6 halogen and in which up to two non-adjacent CH2 units of said C1-C6 alkyl may be replaced with -O -； R2 is H, halogen, CN, or C1-C6 alkyl in which said C1-C6 alkyl is substituted with 0-6 halogen, wherein up to two non-adjacent CH2 units of said C1-C6 alkyl may be substituted with -O- ； R3 is H, halogen, CN, or C1-C6 alkyl in which said C1-C6 alkyl is substituted with 0-6 halogen, wherein up to two non-adjacent CH2 units of said C1-C6 alkyl may be replaced with -O- ； R4 is H, halogen, CN, or C1-C6 alkyl in which said C1-C6 alkyl is substituted with 0-6 halogen, wherein up to two non-adjacent CH2 units of said C1-C6 alkyl may be substituted with -O- ； R5 is H, halogen, CN, or -X-Rx； R5 'is H, halogen, CN, or -X-Rx； R6 is H, halogen, CN, or -X-Rx； R6 'is H, halogen, CN, or -X-Rx； R7 is H, halogen, CN, or -X-Rx； R8 is halogen, or C1-C6 alkyl in which said C1-C6 alkyl is substituted with 0-6 halogen, wherein up to two non-adjacent CH2 units of said C1-C6 alkyl may be substituted with -O-； p is an integer from 0 to 3 inclusive； and R9 is H, or C1-C6 alkyl in which up to two non-adjacent CH2 units of said C1-C6 alkyl may be substituted with -O-.Un compuesto de fórmula I o I' ++Fórmula** o una sal farmacéuticamente aceptable del mismo, en la que, independientemente para cada caso: G es **Fórmula** X es un enlace o C1-C6 alquilo en
