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PYRIDONE AMIDES AS MODULATORS OF SODIUM CHANNELS
专利权人:
VERTEKS FARMASYUTIKALZ INKORPOREJTED
发明人:
ADIDA-RUA Sara Sabina (US),АДИДА-РУА Сара Сабина (US),ANDERSON Kori (US),АНДЕРСОН Кори (US),ARUMUGAM Vidzhayalaksmi (US),АРУМУГАМ Виджаялаксми (US),ASGIAN Iuliana Lyusi (US),АСГИАН Иулиана Люси (US),B,ADIDA-RUA Sara Sabina,АДИДА-РУА Сара Сабина,ANDERSON Kori,АНДЕРСОН Кори,ARUMUGAM Vidzhayalaksmi,АРУМУГАМ Виджаялаксми,ASGIAN Iuliana Lyusi,АСГИАН Иулиана Люси,BEAR Brajan Richard,БЕАР Брайан Ричард,TE
申请号:
RU2015136795
公开号:
RU0002662223C2
申请日:
2014.01.29
申请国别(地区):
RU
年份:
2018
代理人:
摘要:
FIELD: chemistry.SUBSTANCE: invention relates to pyridone amide compounds of formula I and I'where, independently for each case: G isor ;X is a bond or C1-C6 alkyl, wherein said C1-C6 alkyl is substituted with 0-6 halogen atoms, where up to two non-neighbouring CH2 units of said C1-C6 alkyl can be substituted with -O-; Rx is absent, is H or C3-C8 cycloaliphatic group, where up to two non-neighbouring CH2 units of the C3-C8 cycloaliphatic group can be substituted with -O- and said C3-C8 the cycloaliphatic group is substituted with 0-3 substituents selected from halogen and C1-C4 alkyl; R1 is H, halogen, CN or C1-C6 alkyl, where said C1-C6 alkyl is substituted with 0-6 halogen atoms and where up to two non-neighbouring CH2 units of said C1-C6 alkyl can be substituted with -O-; R2 is H, halogen, CN or C1-C6 alkyl, wherein said C1-C6 alkyl is substituted with 0-6 halogen atoms, where up to two non-neighbouring CH2 units of said C1-C6 alkyl can be substituted with -O-; R3 is H, halogen, CN or C1-C6 alkyl, wherein said C1-C6 alkyl is substituted with 0-6 halogen atoms, where up to two non-neighbouring CH2 units of said C1-C6 alkyl can be substituted with -O-; R4 is H, halogen, CN or C1-C6 alkyl, where said C1-C6 alkyl is substituted with 0-6 halogen atoms, where up to two non-neighbouring CH2 units of said C1-C6 alkyl can be substituted with -O-; R5 is H, halogen, CN or -X-Rx; R5’ is H, halogen, CN or -X-Rx; R6 is H, halogen, CN or -X-Rx; R6’ is H, halogen, CN or -X-Rx; R7 is H, halogen, CN or -X-Rx; R8 is a halogen or C1-C6 alkyl, where said C1-C6 alkyl is substituted with 0-6 halogen atoms, where up to two non-neighbouring CH2 units of said C1-C6 alkyl can be substituted with -O-; p is an integer from 0 to 3, inclusively; and R9 is H or C1-C6 alkyl, where up to two non-neighbouring CH2 units of said C1-C6 alkyl can be substituted with -O-.EFFECT: invention relates to pharmaceutically acceptable salts used as inhibitors of sodium channels.48 cl, 4 tbl, 30 exИзобретение о
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