MACDONALD, LYNN,GURER, CAGAN,HOSIAWA, KAROLINA A.,STEVENS, SEAN,MURPHY, ANDREW J.
申请号：
CA2859408
公开号：
CA2859408A1
申请日:
2012.12.17
申请国别(地区):
CA
年份:
2013
代理人:
摘要：
Non-human animals, tissues, cells, and genetic material are provided that comprise a modification of an endogenous non-human heavy chain immunoglobulin sequence and that comprise an ADAM6 activity functional in a mouse, wherein the non-human animals express a human immunoglobulin heavy chain variable domain and a cognate human immunoglobulin ? light chain variable domain.
