DAVID S. F. YOUNG,HELEN P. FINDLAY,SUSAN E. HAHN,LISA M. CECHETTO,FORTUNATA MCCONKEY
申请号：
BRPI0812488
公开号：
BRPI0812488A2
申请日:
2008.05.23
申请国别(地区):
BR
年份:
2014
代理人:
摘要：
This invention relates to the staging, diagnosis and treatment of cancerous diseases (both primary tumors and tumor metastases), particularly to the mediation of cytotoxicity of tumor cells； and most particularly to the use of cancerous disease modifying antibodies (CDMAB), optionally in combination with one or more CDMAB/chemotherapeutic agents, as a means for initiating the cytotoxic response. The invention further relates to binding assays, which utilize the CDMAB of the instant invention. The anti-cancer antibodies can be conjugated to toxins, enzymes, radioactive compounds, cytokines, interferons, target or reporter moieties and hematogenous cells.
