A personal audio device, such as a wireless telephone, includes noise canceling circuit that adaptively generates an anti-noise signal from a reference microphone signal and injects the anti-noise signal into the speaker or other transducer output to cause cancellation of ambient audio sounds. An error microphone may also be provided proximate the speaker to estimate an electro-acoustical path from the noise canceling circuit through the transducer. A processing circuit uses the reference and/or error microphone, optionally along with a microphone provided for capturing near-end speech, to determine whether one of the reference or error microphones is obstructed by comparing their received signal content and takes action to avoid generation of erroneous anti-noise.