JIANG, GUANG-LIANG,TURKEL, CATHERINE C.,STERN, MICHAEL,SCHAUMBURG, CHRISTOPHER S.,BLANDA, WENDY
申请号：
CA2973374
公开号：
CA2973374A1
申请日:
2016.01.28
申请国别(地区):
CA
年份:
2016
代理人:
摘要：
The present invention relates to formulations for administration to a joint fat pad of a subject, and to methods of treating joint pain, inflammation or disease. The disclosed formulations are intended for local administration to the joint fat pad to provide sustained release of a therapeutic agent to the joint cavity and surrounding tissues. The joint may be an arthritic joint, an injured joint or a surgically replaced joint. The therapeutic agent may be an analgesic agent, an anti-inflammatory agent or an immunosuppressive agent. A single administration of the formulation to the joint fat pad delivers a therapeutically effective amount of the therapeutic agent with reduced systemic exposure relative to a single systemic or a single intra-articular administration of a therapeutic dose of an identical therapeutic agent.
