Jiang, Guang-Liang,Turkel, Catherine C.,Stern, Michael,Schaumburg, Christopher S.,Blanda, Wendy
申请号:
AU2020220180
公开号:
AU2020220180A1
申请日:
2020.08.21
申请国别(地区):
AU
年份:
2020
代理人:
摘要:
#$%^&*AU2020220180A120200910.pdf#####JOINT FAT PAD FORMULATIONS, AND METHODS OF USE THEREOF Abstract The present invention relates to formulations for administration to a joint fat pad of a subject, and to methods of treating joint pain, inflammation or disease. The disclosed formulations are intended for local administration to the joint fat pad to provide sustained release of a therapeutic agent to the joint cavity and surrounding tissues. The joint may be an arthritic joint, an injuredjoint or a surgically replaced joint. The therapeutic agent may be an analgesic agent, an anti-inflammatory agent or an immunosuppressive agent. A single administration of the formulation to the joint fat pad delivers a therapeutically effective amount of the therapeutic agent with reduced systemic exposure relative to a single systemic or a single intra-articular administration of a therapeutic dose of an identical therapeutic agent.