RUBINO, ORAPIN P.,JONES, DAVID M.,BRETSCHNEIDER, FRANK,FANKHAUSER, PETER,PRASCH, ARMIN
申请号：
ES03796707
公开号：
ES2545454T3
申请日:
2003.12.04
申请国别(地区):
ES
年份:
2015
代理人:
摘要：
Process for producing microgranules adapted for biologically active preparations comprising a core and optionally one or more layers surrounding said core, the method comprising feeding powder particles into a suitable device for contacting and adhering said particles, in which the device comprises a rotor, a chamber in which said rotor is located and mechanical guide means disposed above said rotor, wherein said core and / or at least one of said layers is formed by contacting said dust particles, adhering them together and compacting said adhered particles by means of a rolling movement, in which the rolling movement of the microgranules that are being formed is produced by the rotation of said rotor, and the microgranules that are forming that move in one direction outward. of said rotor, after leaving said rotor, they are guided back on said r granted by said mechanical guide means, in which the degree of densification is controlled by the capture of energy during the rolling movement, in which the capture of energy is regulated by selecting the rotor speed, at which the rotor speed It confers a radial speed, measured at the tip of the rotor, from 3 to 30 meters / second.Procedimiento para producir microgránulos adaptados para preparaciones biológicamente activas que comprenden un núcleo y opcionalmente una o más capas rodeando a dicho núcleo, comprendiendo el procedimiento alimentar partículas de polvo al interior de un dispositivo adecuado para poner en contacto y adherir dichas partículas, en el que el dispositivo comprende un rotor, una cámara en la que está ubicado dicho rotor y medios de guía mecánicos dispuestos por encima de dicho rotor, en el que dicho núcleo y/o al menos una de dichas capas se forma poniendo en contacto dichas partículas de polvo, adhiriéndolas entre sí y compactando dichas partículas adheridas mediante un movimiento de rodadura, en el que el movimiento de rodadura de los microgránulos que están formándose se produce por la rotación de
