Campana, Manuela,Viscomi, Giuseppe Claudio,Rosini, Goffredo,Braga, Dario,Confortini, Donatella,Cannata, Vincenzo,Righi, Paolo,Severini, Denis
申请号：
NO20061110
公开号：
NO334950B1
申请日:
2006.03.08
申请国别(地区):
NO
年份:
2014
代理人:
摘要：
Crystalline polymorphous forms of the rifaximin (INN) antibiotic named rifaximin alpha and rifaximin beta , and a poorly crystalline form named rifaximin y have been discovered. These forms are useful in the production of medicinal preparations for oral and topical use and can be obtained by means of a crystallization process carried out by hot-dissolving the raw rifaximin in ethyl alcohol and by causing the crystallization of the product by the addition of water at a determinate temperature and for a determinate period of time. The crystallization is followed by drying carried out under controlled conditions until a specific water content is reached in the end product.
