Giuseppe Claudio VISCOMI,Manuela CAMPANA,Dario BRAGA,Donatella CONFORTINI,Vincenzo CANNATA,Paolo RIGHI,Goffredo ROSINI,Denis SEVERINI
申请号：
US16409398
公开号：
US20190263830A1
申请日:
2019.05.10
申请国别(地区):
US
年份:
2019
代理人:
摘要：
Crystalline polymorphous forms of rifaximin (INN), referred to as rifaximin α and rifaximin β, and a poorly crystalline form referred to as rifaximin γ, useful in the production of medicaments containing rifaximin for oral and topical use and obtained by means of a crystallization process carried out by hot-dissolving the raw rifaximin in ethyl alcohol and by causing the crystallization of the product by addition of water at a fixed temperature and for a fixed period of time, followed by a drying under controlled conditions until reaching a precise water content in the end product, are the object of the invention.
