LUIS ANGLADA,ALBERT PALOMER,LUIS SOBRAL,CARLOS ALVAREZ
申请号：
IN3608/DELNP/2012
公开号：
IN2012DN03608A
申请日:
2012.04.25
申请国别(地区):
IN
年份:
2015
代理人:
摘要：
This invention relates to a new process for preparing (11ß, 16α)-9-fluoro-11-hydroxy-16,17-[1 -methyl-ethylidenebis(oxy)]-21 -[1 -oxo-[4-(nitrooxymethyl)benzoxy]]pregna-1,4-dien-3,20-dione, comprising the steps of (i) reaction of triamcinolone acetonide with 4-(nitrooxymethyl)benzoic, 4-dimethylaminopyridine and N-N"-diisopropylcarbodiimide, (ii) crystallisation, and (iii) controlled precipitation.
