PROCESS FOR PREPARING (11BETA, 16ALPHA)-9-FLUORO-11-HYDROXY-16,17-[1-METHYL-ETHYLIDENEBIS(OXY)]-21-[1-OXO-[4-(NITROOXYMETHYL)BENZOXY]]PREGNA-1,4-DIEN-3,20-DIONE
ANGLADA LUIS,앤글라다, 루이스,PALOMER ALBERT,팔로머, 알베르트,SOBRAL LUIS,소브랄, 루이스,ALVAREZ CARLOS,알바레즈, 카를로스
申请号：
KR1020127015331
公开号：
KR1020120084788A
申请日:
2010.11.15
申请国别(地区):
KR
年份:
2012
代理人:
摘要：
This invention relates to a new process for preparing (11 ß, 16a)-9-fluoro-11 - hydroxy-16,17-[1 -methyl -ethyl idenebis(oxy)]-21 -[1 -oxo-[4- (nitrooxymethyl)benzoxy]]pregna-1,4-dien-3,20-dione, comprising the steps of (i) reaction of triamcinolone acetonide with 4-(nitrooxymethyl)benzoic, 4- dimethylaminopyridine and N-N'-diisopropylcarbodiimide, (ii) crystallisation, and (iii) controlled precipitation.본 발명은 (ⅰ) 트리암시놀론 아세노나이드와 4-(니트로옥시메틸)벤조산, 4-디메틸아미노피리딘 및 N-N'-디이소프로필카르보디이미드의 반응 단계, (ⅱ) 결정화 단계 및 (ⅲ) 조절된 침전 단계를 포함하는, (11β, 16α)-9-플루오로-11-하이드록시-16,17-[1-메틸-에틸리덴비스(옥시)]-21-[1-옥소-[4-(니트로옥시메틸)벤조옥시]]프레그나-1,4-디엔-3,20-디온을 제조하기 위한 신규한 공정에 관한 것이다.
