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COMPUESTOS FARMACEUTICOS.
专利权人:
SAREUM LIMITED
发明人:
John Charles READER
申请号:
MX2016002738
公开号:
MX369974B
申请日:
2013.09.03
申请国别(地区):
MX
年份:
2019
代理人:
摘要:
The invention provides a compound which is an amide of the formula (2): or a salt or stereoisomer thereof; wherein: R7 is selected from chlorine and fluorine; R3, R4, R5 and R6 are each independently selected from hydrogen, fluorine and chlorine; n is 0, 1 or 2; Q1 is selected from C(=O), S(=O) and SO2; A is absent or is NR2; R1 is selected from: - hydrogen; - an optionally substituted C1-6 non-aromatic hydrocarbon group; and - 3- to 7-membered non-aromatic carbocyclic and heterocyclic rings containing one or two heteroatom ring members selected from O, N and S, and bridged bicyclic heterocyclic rings of seven to nine ring members of which one or two are nitrogen atoms, the carbocyclic and heterocyclic rings and bridged bicyclic heterocyclic rings being optionally substituted; R2 is selected from hydrogen and C1-4 alkyl; or NR1R2 forms an optionally substituted 4- to 7-membered non-aromatic nitrogen- containing heterocyclic ring optionally containing a second heteroatom ring member selected from nitrogen and oxygen; with the provisos that: (i) no more than two of R3 to R6 are other than hydrogen; and (ii) when R7 and R6 are both fluorine, then one of R3 to R5 is chlorine or fluorine and/or R1-A-Q1 is selected from ethylsulfonyl and isopropylsulfonyl. Also provided are pharmaceutical compositions containing the compounds and their therapeutic uses.La invención proporciona un compuesto que es una amida de la fórmula (2): (ver fórmula2) o una sal o estereoisómero del mismo; en donde: R7 se selecciona de cloro y flúor; R3, R4, R5 y R6 son cada uno seleccionados independientemente de hidrógeno, flúor y cloro; n es 0, 1 ó 2; Q1 se selecciona de C(=0), S(=0) y SO2; A está ausente o es NR2; R1 se selecciona de: - Hidrógeno; - Un grupo hidrocarbonado no aromático C1-6 opcionalmente sustituido; y anillos carbocíclicos y heterocíclicos no aromáticos de 3 a 7 miembros que contienen uno o dos miembros de anillo heteroatómicos seleccionado de O, N y S, y anillos heterocíclicos bi
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