MOIR, Donald,AIELLO, Daniel,PEET, Norton,WILLIAMS, John,TORHAN, Matthew
申请号：
ES12812134
公开号：
ES2672719T3
申请日:
2012.07.13
申请国别(地区):
ES
年份:
2018
代理人:
摘要：
Bacterial Type III Secretion System (T3SS) Inhibitor Compound of Formula I: ** Formula ** wherein: A is independently CH or N, X is independently selected from hydrogen or halogen, Z is O, S , NH； or NR3, where R3 is alkyl, V is NR2, O, or CR3R4, R2, R3, and R4 are independently hydrogen or alkyl, and is selected from: a branched, straight-chain, alkyl, alkenyl, or alkynyl radical or divalent cyclic of 1 to 6 carbon atoms, which may contain one or more heteroatoms and which may be unsubstituted or substituted with up to four substituents selected from halo, cyano, hydroxy, amino, alkylamino, carboxyl, alkoxycarbonyl, carboxamido, acylamino , amidino, sulfonamido, aminosulfonyl, alkylsulfonyl, aryl, heteroaryl, alkoxy, alkylthio, aryloxy and heteroaryloxy oxygen, or NR5, where R5 is hydrogen or alkyl, W is an aryl or heteroaryl radical that forms a ring of five or six elements which may be further fused with 1 to 3 aryl, heteroaryl, cycloalkyl or heterocycloalkyl rings, the radical of which may be unsubstituted or substituted with up to four substituents selected from halo, c iano, hydroxy, amino, alkylamino, carboxyl, alkoxycarbonyl, carboxamido, acylamino, amidino, sulfonamido, aminosulfonil, alkylsulfonyl, aryl, heteroaryl, alkoxy, alkylthio, aryloxy and heteroaryloxy, and in which any two substituents can together form a ring structure aromatic or non-aromatic fused with said aryl or heteroaryl radical W, in which the substituents observed in W can also optionally covalently bind to Y or R2, or both, forming heterocyclic or carbocyclic ring systems, in which the systems of rings can be aromatic, heteroaromatic or partially aromatic.Compuesto inhibidor del sistema de secreción de tipo III bacteriano (T3SS) de fórmula I: **Fórmula** en la que: A es independientemente CH o N, X se selecciona, independientemente, de entre hidrógeno o halógeno, Z es O, S, NH； o NR3, en la que R3 es alquilo, V es NR2, O, o CR3R4, R2, R3 y R4 son, independientemente, hidrógeno o alquilo
