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2-phenylimidazo [1,2-a] pyrimidines as imaging agents
专利权人:
H. Hoffnabb-La Roche Ag
发明人:
GOBBI, Luca,KNUST, Henner,KOERNER, Matthias,MURI, Dieter
申请号:
ES14724757
公开号:
ES2629389T3
申请日:
2014.05.19
申请国别(地区):
ES
年份:
2017
代理人:
摘要:
A compound of formula ** Formula ** in which R1 is phenyl, optionally substituted with one or two substituents, selected from 3H, halogen, C1-7-alkyl, dimethylamino, NHC (O) -C1-7-alkyl, C (O ) O- C1-7alkyl, C1-7alkoxy, OC (3H) 3, O11CH3, OCH2CH2 18F, C1-7alkoxy substituted with halogen, hydroxy, C1-7alkyl substituted with hydroxy, S-C1-7alkyl, or with a heterocyclyl group, selected from morpholinyl, piperazinyl, piperidinyl, or pyrrolidinyl; o is benzo [d] [1,3] dioxol-5-yl, 2,3-dihydrobenzo [b] [1,4] dioxin-6-yl, indolin-2-one, or is heteroaryl, selected from the group that it consists of thiophenyl, benzofuranyl, benzothiophenyl, pyrazinyl, or benzothiazolyl; R2 is hydrogen, C1-7 alkyl or halogen-substituted C1-7 alkyl; R3 is C1-7alkyl, C (3H) 3, 11CH3, halogen-substituted C1-7alkyl, - (CH2) 2-O-C1-7alkyl substituted with halogen or C3-6cycloalkyl; or R2 and R3 together with the N atom to which they are attached form a ring containing -CH2CH2CHRCH2CH2-, -CH2CH2CH2CH2-, -CH2CH2CH2-, -CH2CH2-NR-CH2CH2-, -CH2CH2-O-CH2CH2-, - CH2CH2CHRCH2-, -CH2CHRCH2- or R is hydrogen, halogen, C1-7 alkyl substituted with halogen or C1-7 alkoxy; or a pharmaceutically acceptable acid addition salt, a racemic mixture or its corresponding enantiomer and / or optical isomers thereof.Un compuesto de fórmula**Fórmula** en la que R1 es fenilo, sustituido opcionalmente con uno o dos sustituyentes, seleccionados de 3H, halógeno, alquilo C1-7, dimetilamino, NHC(O)-alquilo C1-7, C(O)O-alquilo C1-7, alcoxi C1-7, OC(3H)3, O11CH3, OCH2CH2 18F, alcoxi C1-7 sustituido con halógeno, hidroxi, alquilo C1-7 sustituido con hidroxi, S-alquilo C1-7, o con un grupo heterociclilo, seleccionado de morfolinilo, piperazinilo, piperidinilo o pirrolidinilo; o es benzo[d][1,3]dioxol-5-ilo, 2,3-dihidrobenzo[b][1,4]dioxin-6-ilo, indolin-2-ona, o es heteroarilo, seleccionado del grupo que consiste en tiofenilo, benzofuranilo, benzotiofenilo, pirazinilo o benzotiazolilo; R2 es hidrógeno, alquilo C1-7 o alquilo C1-7 s
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