BIEMANS, Barbara,GUBA, Wolfgang,JAESCHKE, Georg,RICCI, Antonio,RUEHER, Daniel,VIEIRA, Eric
申请号：
ES14781474
公开号：
ES2630319T3
申请日:
2014.09.22
申请国别(地区):
ES
年份:
2017
代理人:
摘要：
Compounds of formula I ** Formula ** in which Y is N or C-R1 '； G is a 5- or 6-membered aromatic or heteroaromatic ring containing 0, 1, 2 or 3 heteroatoms, selected from the group consisting of phenyl, pyridinyl with different positions of N, imidazolyl, pyrazinyl, pyrimidinyl, thiophenyl, thiazolyl, pyrazolyl or thiadiazolyl, which are optionally substituted with 1, 2 or 3 substituents, selected from the group consisting of halogen, C1-7 alkyl, C1-7 alkoxy, C1-7 alkoxy substituted with halogen or NRR '； R and R 'are independently from each other hydrogen or C1-7 alkyl, or may form together with the N atom to which a saturated five or six membered heterocyclic group is attached which may contain an oxygen, NH or N-C1-alkyl group -C7 additional； R1 is hydrogen, halogen or C1-7 alkyl substituted with halogen； R1 'is hydrogen, halogen or C1-7 alkyl substituted with halogen； R2 is hydrogen, C1-7 alkyl, C1-7 alkoxyalkyl, cycloalkyl or heterocycloalkyl； or R2 may form together with the closest carbon atom of group G a group ** Formula ** in which A is -CH2-, -CH2CH2, or -C (CH3) 2-, R3 is phenyl or pyridinyl, in that the N atom in the pyridinyl group may be in different positions； or a pharmaceutically acceptable acid addition salt or salt, a racemic mixture, or its corresponding enantiomer and / or optical isomer and / or stereoisomer thereof.Compuestos de fórmula I**Fórmula** en la que Y es N o C-R1'； G es un anillo aromático o heteroaromático de 5 o 6 miembros que contiene 0, 1, 2 o 3 heteroátomos, seleccionado del grupo que consiste en fenilo, piridinilo con diferentes posiciones de N, imidazolilo, pirazinilo, pirimidinilo, tiofenilo, tiazolilo, pirazolilo o tiadiazolilo, que están opcionalmente sustituidos con 1, 2 o 3 sustituyentes, seleccionados del grupo que consiste en halógeno, alquilo C1-7, alcoxi C1-7, alcoxi C1-7 sustituido con halógeno o NRR'； R y R' son independientemente entre sí hidrógeno o alquilo C1-7, o pueden formar junto con el átomo de N al que est
