JOHNSON, Ted William,RICHARDSON, Paul Francis,COLLINS, Michael Raymond,RICHTER, Daniel Tyler,BURKE, Benjamin Joseph,GAJIWALA, Ketan,NINKOVIC, Sacha,LINTON, Maria Angelica,LE, Phuong Thi Quy,HOFFMAN, J
申请号：
ES15812888
公开号：
ES2746839T3
申请日:
2015.12.04
申请国别(地区):
ES
年份:
2020
代理人:
摘要：
A compound of Formula (I): ** Formula ** where: each of X is N or CR6, where at least one of X is N, where each R6 is independently selected from the group consisting of in hydrogen, halogen, (C1-C8) alkyl, (C2-C3) alkenyl, (C1-C8) alkynyl, (C1-C8) haloalkyl, -C1-C4 alkylene-R7, -OR7, -CN, - NO2 and -NR7R7, where each R7 is independently selected from the group consisting of hydrogen and (C1-C8) alkyl and wherein each of said (C1-C8) alkyl at R6 is optionally substituted with one or more substituents independently selected from the group consisting of halogen, hydroxyl, and (C1-C8) alkoxy； Y is Y1-Y2 or Y2-Y1, where Y1 is absent or is (C1-C8) alkylene, and where Y2 is absent or is oxygen； Z is Z1-Z2, where each of Z1 and Z2 is independently absent or selected from the group consisting of (C1-C8) alkylene, (C2-C8) alkenylene, (C3-C10) cycloalkyl, heterocyclyl of 3-12 membered and (C1-C8) heteroalkylene, where Z is optionally independently substituted with one or more R10, where each R10 is independently selected from the group consisting of halogen, (C1-C8) alkyl , - CN, = O, -OR11 and -NO2, and wherein each R11 is independently selected from the group consisting of hydrogen, (C1-C8) alkyl, (C3-C10) cycloalkyl, 3-12 membered heterocyclyl , C6-C12 aryl and 5-12 membered heteroaryl； each R1 is independently selected from the group consisting of hydrogen, halogen, (C1-C8) alkyl, halo (C1-C8) alkyl, - (C1-C4 alkyl) R7, -OR7, -CN, -C (O) R7 , -CO2R7, -C (O) NR7R7, -SR7, -SOR7, -SO2R7, -SO2NR7R7, -NO2, -NR7R7, -NR7C (O) R7, -NR7C (O) NR7R7, -NR7C (O) OR7, -NR7SO2R7, -NR7SO2NR7R7, -OC (O) R7 and -OC (O) NR7R7； wherein any set of two R1s on the same or different piperidine carbons are optionally linked to form a spirocyclic, fused or bridged ring system comprising of 1-4 non-piperidine members and 1-2 heteroatoms selected from N, O and S, and wherein any set of two R1s on the adjacent piperidine carbons optionally join to form a carbon-carbon bond； R2 and R3 are each indepen
