LEMIEUX, Rene M.,POPOVICI-MULLER, Janeta,SALITURO, Francesco G.,SAUNDERS, Jeffrey O.,TRAVINS, Jeremy M.,CHEN, Yongsheng
申请号：
ES13857585
公开号：
ES2690390T3
申请日:
2013.11.21
申请国别(地区):
ES
年份:
2018
代理人:
摘要：
A compound of formula (II) or a pharmaceutically acceptable salt thereof: ** Formula ** wherein X is a C3-C7 cycloalkylene each R1 and R2 is independently -NH2, -N (R3) -C (O) -R4 , -C (O) -N (R3) -R4, -N (R3) -C (O) -O-R4, -N (R3) -C (O) -N (R3) -R4 or -N ( R3) -C (O) -SR4； each R3 is independently hydrogen, C1-6 alkyl or aryl； each R4 is independently C1-6 alkyl, aryl, heteroaryl, aralkyl, heteroaralkyl, cycloalkyl, cycloalkylalkyl, heterocyclylalkyl or heterocyclyl, each of which is substituted with 0-3 occurrences of R5； each R5 is independently C1-6 alkyl, C1-6 alkoxy, -O-C1-6 alkylene, C1-6 alkoxy, -O-heterocyclyl, C1-6 thioalkoxy, C1-6 haloalkyl, C3-7 cycloalkyl, C3- cycloalkylalkyl 7, aryl, heteroaryl, aralkyl, heteroaralkyl, heterocyclylalkyl, heterocyclyl, cyano, halo, oxo, -OH, -OCF3, -OCHF2, -SO2-C1-6 alkyl, -NO2, -N (R7) -C (O) -C1-6 alkyl, -C (O) N (R7) 2, - N (R7) S (O) 1-2-C1-6 alkyl, -S (O) 2N (R7) 2, -N (R7 ) 2 or -C1-6-N alkylene (R7) 2, wherein said alkyl, C1-6 alkoxy, -O C1-6 alkylene, C1-6 alkoxy, -O-heterocyclyl, C1-6 thioalkoxy, C1- haloalkyl 6, C3-7 cycloalkyl, C3-7 cycloalkylalkyl, aryl, heteroaryl, aralkyl, heteroaralkyl, heterocyclylalkyl, heterocyclyl, -SO2-C1-6 alkyl, -NO2, -N (R7) -C (O) -C1-6 alkyl , -C (O) N (R7) 2, -N (R7) S (O) 1-2-C1-6 alkyl, -S (O) 2N (R7) 2, -N (R7) 2, or alkylene C1-6- N (R7) 2 is optionally substituted with 0-3 occurrences of R8； or two other adjacent R5 structural units, taken together with the atoms to which they are attached form a cycloalkyl or heterocyclyl； each R6 is independently hydrogen, fluorine, C1-6 alkyl, -OH, -NH2, -NH (CH3), -N (CH3) 2 or C1-6 alkoxy； each R7 is independently hydrogen or C1-6 alkyl； each R8 is independently halo, C1-6 alkyl, C1-6 haloalkyl, -OH, -N (R7) 2 or C1-6 alkoxy, -O-C1-6 alkylene C1-6 alkoxy, CN, NO2, -N ( R7) -C (O) -C1-6 alkyl, -C (O) N (R7) 2, -N (R7) S (O) 1-2 C1-6 alkyl, or -S (O) 2N (R7 )2； m is 0, 1 or 2； n is 0, 1 or 2； or is 1 p is 1 and where "alkyl" refers to
