Kasparec Jiri,Luengo Juan I,Johnson Neil W.,Miller William Henry,Tian Xinrong,Burgess Joelle Lorraine,Su Dai-Shi,Blackledge Jr. Charles William,Romeril Stuart Paul,Newlander Kenneth Allen,Schulz Mark
申请号：
NZ63020514
公开号：
NZ630205A
申请日:
2014.04.25
申请国别(地区):
NZ
年份:
2017
代理人:
摘要：
The disclosure relates to methylthiophene-2-carboxamide derivative compounds according to formula (I) which are inhibitors of Enhancer of Zeste Homolog 2 (EZH2), to pharmaceutical compositions containing them, to processes for their preparation, and to their use in therapy for the treatment of cancer selected from the group consisting of: brain (gliomas), glioblastomas, leukemias, lymphomas, Bannayan-Zonana syndrome, Cowden disease, Lhermitte-Duclos disease, breast, inflammatory breast cancer, Wilm’s tumor, Ewing’s sarcoma, Rhabdomyosarcoma, ependymoma, medulloblastoma, colon, gastric, bladder, head and neck, kidney, lung, liver, melanoma, renal, ovarian, pancreatic, prostate, sarcoma, osteosarcoma, giant cell tumor of bone, and thyroid.
