After as for this invention, flexibility insufficiency is improved, cohesion of the grain is difficult to happen, at the same time, the catheter and the like passing, the spherical biodegradation Characteristic grain where restoring force of the form of particle in improves and that its production manner is offered are designated as purpose. This invention becomes, the synthetic polymer and the polyvalent carboxylic acid building a bridge, chemistry, percentage of water content in saturation hydrous state is 20 - 90%, the biodegradation Characteristic grain is offered.本発明は、柔軟性不足が改善され、粒子同士の凝集が起こりにくく、かつ、カテーテル等を通過した後における粒子形状の復元力が向上した球状の生分解性粒子及びその製造方法を提供することを目的としている。本発明は、合成ポリマーと、多価カルボン酸とが化学架橋されてなり、飽和含水状態での含水率が20~90%である、生分解性粒子を提供する。
