A compound of the formula ** (See formula) ** or a pharmaceutically acceptable salt thereof, wherein q is 0, 1 or 2； s is 0, 1 or 2； R3, each time it is taken, is independently selected from the group consisting of hydrogen, hydroxyl, amino, C1-8 alkylamino, cyano, halo, optionally substituted C1-6 alkyl, and C1-4 alkoxy； R4 is selected from the group consisting of hydrogen, cyano, halo, methyl, ethyl, methoxy, and trifluoromethyl； R5 is selected from the group consisting of ** (See formula) ** G is carbon； A is selected from the group consisting of N, O, S, CR6 and NR6； E is selected from the group consisting of N, O, S, and CR6； with the proviso that only one of A and E can be O or S； or G is N and A and E are CR6； or G and A are N and E is CR6； or G, A, and E are N； R6, each time it is taken, is independently selected from the group consisting of hydrogen, cyano, halo, C3-8 cycloalkyl, optionally substituted C1-6 alkyl, C1-4 alkoxy, and trifluoromethyl； R7 is selected from the group consisting of cyano and cyanomethyl； R8, each time it is taken, is independently selected from the group consisting of hydrogen, cyano, halo, C1-4 alkyl, C1-4 alkoxy, and trifluoromethyl； and R9 is selected from the group consisting of hydrogen, C1-6 alkyl optionally substituted with 1 to 3 fluorine, and C3-8 cycloalkyl.Un compuesto de la fórmula **(Ver fórmula)** o una sal farmacéuticamente aceptable del mismo, en la que q es 0, 1 o 2； s es 0, 1 o 2； R3, cada vez que se toma, se selecciona independientemente del grupo que consiste en hidrógeno, hidroxilo, amino, alquilamino C1-8, ciano, halo, alquilo C1-6 opcionalmente sustituido, y alcoxi C1-4； R4 se selecciona del grupo que consiste en hidrógeno, ciano, halo, metilo, etilo, metoxi, y trifluorometilo； R5 se selecciona del grupo que consiste en **(Ver fórmula)** G es carbono； A se selecciona del grupo que consiste en N, O, S, CR6 y NR6； E se selecciona del grupo que consiste en N, O, S, y CR6； con la condición de que solamente uno de
