CANNIZZARO, Carina,GRAUPE, Michael,GUERRERO, Juan,LU, Yafan,STRICKLEY, Robert,VENKATARAMANI, Chandrasekar,ZABLOCKI, Jeff
申请号：
ES12735394
公开号：
ES2553829T3
申请日:
2012.06.29
申请国别(地区):
ES
年份:
2015
代理人:
摘要：
A compound of Formula (la): ** Formula ** in which: R1 is hydrogen, optionally substituted C1-6 alkyl, -CH2OH, -CH2OP (O) (OR20) (OR21), -C (O) R22 or -SO2R23； R2 is hydrogen, optionally substituted C1-6 alkyl, cycloalkyl or halo； each of R3, R4, R5, R6, R9, R10, R11, R12 and R13 is independently hydrogen, hydroxyl, -OP (O) (OR20) (OR21), -CH2OH, -CH2OP (O) (OR20) ( OR21), optionally substituted alkyl, optionally substituted alkylene, optionally substituted alkynyl, optionally substituted alkoxy, optionally substituted cycloalkyl, optionally substituted aryl, optionally substituted aralkyl, optionally substituted heteroaryl, optionally substituted heteroaralkyl, optionally substituted heterocyclyl, aminocarbonyl, acyl, acylamino O- (C1 to C6 alkyl) -O- (C1 to C6 alkyl), cyano, halo, -SO2NR24R25； or -NR24R25； R7 is hydrogen or optionally substituted C1-6 alkyl； each of R20 and R21 is independently Na +, Li +, K +, hydrogen, C1-6 alkyl； or R20 and R21 can be combined to represent a single divalent cation of Zn2 +, Ca2 + or Mg2 +. each of R22 and R23 is independently optionally substituted alkyl, optionally substituted alkoxy, optionally substituted cycloalkyl, optionally substituted aryl or -NR24R25； and each of R24 and R25 is independently selected from hydrogen or C1-6 alkyl or when combined together with the nitrogen to which they are attached form a heterocycle； or a salt, an ester, an individual stereoisomer, a mixture of stereoisomers or a pharmaceutically acceptable tautomer thereof.Un compuesto de Fórmula (la):**Fórmula** en la que: R1 es hidrógeno, alquilo C1-6 opcionalmente sustituido, -CH2OH, -CH2OP(O)(OR20)(OR21), -C(O)R22 o -SO2R23； R2 es hidrógeno, alquilo C1-6 opcionalmente sustituido, cicloalquilo o halo； cada uno de R3, R4, R5, R6, R9, R10, R11, R12 y R13 es independientemente hidrógeno, hidroxilo, -OP(O)(OR20)(OR21), -CH2OH, -CH2OP(O)(OR20)(OR21), alquilo opcionalmente sustituido, alquileno opcionalmente sustituido, alquinilo opcionalmente sustituido
