JOHN ADAM WENDT,SUSAN MARY KULT SHEEHAN,TOMASZ RESPONDEK,GRAHAM M. KYNE,CHRISTOPHER SCOTT KNAUER,RICHARD ANDREW EWIN,JINXIA NANCY DENG,MICHAEL P. CURTIS,GOVINDAN SUBRAMANIAN
申请号：
ARP160101875
公开号：
AR105097A1
申请日:
2016.06.22
申请国别(地区):
AR
年份:
2017
代理人:
摘要：
Claim 1: a compound characterized by formula (1), wherein r74919,R74959,R¹ᶜ and R¹ᵈ are each independently selected from the group consisting of hydrogen, halo, C₁₋₆ alkyl,C₂₋₆ alkenyl,C₃₋₆ cycloalkyl,C₁₋₆ alkoxy,C₁₋₆ haloalkyl,C₁₋₆ haloalkoxy,-C (o) No. 7491； (r7495)；cyano, -S (O) ₚR, phenyl, pyridinyl, saturated or partially saturated 5 or 6-membered heterocyclic ring containing at least one heteroatom selected from the group consisting of N, S, and O, and wherein said heterocyclic ring , phenyl or pyridinyl moiety are each optionally and independently substituted with at least one substituent selected from the group consisting of oxo, cyano, halo and C₁₋₆ alkyl；or R¹ᵃ and R¹ᵇ or R¹ᵇ and R¹ᶜ or R¹ᶜ and R¹ᵈ together form a tetrahydrofuran ring or a phenyl ring； R² is phenyl or a 5- or 6-membered heteroaryl ring containing at least one heteroatom selected from the group consisting of N, S, or O, and wherein said phenyl or heteroaryl ring is optionally and independently substituted with at least one R⁵ substituent selected from the group consisting of halo, C₁₋₆ alkyl,C₁₋₆ haloalkyl,hydroxyl, C₁₋₆ alkoxy and C₃₋₆ cycloalkyl；R³ is C alquilar alkylaryl,C₁₋₄ alkylheteroaryl,C₂₋₆ alkenyl or C₂₋₆ alkenylheteroaryl；and wherein each aryl and heteroaryl moiety is optionally and independently substituted with at least one R⁴ substituent selected from the group consisting of halo, cyano, C₁₋₆ alkoxy,C₁₋₆ haloalkyl,1. Lease land No. c833218331 and 832626；haloalkoxy C₁₋₆ and S (O) ₚR； and wherein the alkenyl moiety is optionally substituted with halo； Rᵃ and Rᵇ are each independently selected from the group consisting of H and C₁₋₆ alkyl；R is H or C₁₋₆ alkyl；P is an integer of 0, 1, or 2. In this line, the dotted line - is a simple or double link, a salt acceptable to veterinarians, and their stereoisomers.Reivindicación 1: Un compuesto caracterizado por la fórmula (1) en la que R¹ᵃ, R¹ᵇ, R¹ᶜ y R¹ᵈ están seleccionados cada uno independientemente del grupo que consiste en hidróge
