Refers to a compound of General formula I, where R1 is Hydrogen, halogen, among others R2 is Hydrogen, C1 to C6 alkyl -, among others R3 is Hydrogen, C1 - C6 C3 C6 alkyl, cycloalkyl, among others.Preferred compounds are: (RS) - n, N - Dimethyl 4 (pyrazolo [1,5-a] pyridin - 5 - ilamino) - 5,6,7,8-tetrahydro [1] benzotieno [2,3-d] pyrimidine - 7 - carboxamide acid (7S) - 4 - (pyrazolo [1,5-a] pyridin - 5 - ilamino) - 5,6,7,8-tetrahydro [1] benzotieno [2,3-d] pyrimidine carboxylic - 7 among others. It also relates to a preparation method and a Pharmaceutical composition.These compounds are derived from pirazolpiridinamina inhibitors of kinases and mknk2 mknk1, being useful in the treatment of disorders hiperproliferativos, inflammatory disease, among others.Se refiere a un compuesto de formula general I, donde: R1 es hidrogeno, halogeno, entre otros R2 es hidrogeno, C1-C6 alquilo, entre otros R3 es hidrogeno, C1-C6 alquilo, C3-C6 cicloalquilo, entre otros. Son compuestos preferidos: (RS) N,N-dimetil-4-(pirazolo[1,5-a]piridin-5-ilamino)-5,6,7,8-tetrahidro[1]benzotieno[2,3-d]pirimidina-7-carboxamida Acido (7S)-4-(pirazolo[1,5-a]piridin-5-ilamino)-5,6,7,8-tetrahidro[1]benzotieno[2,3-d]pirimidina-7-carboxilico entre otros. Tambien se refiere a un metodo de preparacion y a una composicion farmaceutica. Dichos compuestos son derivados de pirazolpiridinamina inhibidores de las quinasas MKNK1 y MKNK2, siendo utiles en el tratamiento de trastornos hiperproliferativos, enfermedad inflamatoria, entre otros.
