COMPOSÉS DE TRIAZOLOPYRIDAZINE, UTILISATION COMME INHIBITEURS DE LA KINASE LRRK2, ET PROCÉDÉS POUR LEUR PRÉPARATION

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专利权人:

SOUTHERN RESEARCH INSTITUTE;THE UAB RESEARCH FOUNDATION

发明人:

GALEMMO, ROBERT, A.,WEST, ANDREW, B.,MADDRY, JOSEPH, A.,ANANTHAN, SUBRAMANIAM,PATHAK, ASHISH, KUMAR,VALIYAVEETTIL, JACOB

申请号：

EP13784613

公开号：

EP2844660A4

申请日:

2013.05.02

申请国别(地区):

EP

年份:

2015

代理人:

摘要：

Provided are novel LRRK2 kinase inhibitors and methods of treating disease states using these inhibitors. Examples of LRRK2 kinase inhibitors are compounds of the formula: or derivatives thereof. An example is 1-(piperidin-1-yl)-2-((3-(thiophen-2-yl)-[1,2,4]triazolo[4,3-b]pyridazin-6-yl)thio)butan-1-one. Particular uses include treating neurodegenerative diseases, cancer, autoimmune diseases and leprosy.

来源网站：

中国工程科技知识中心

来源网址：

http://www.ckcest.cn/home/