Southern Research Institute;THE UAB RESEARCH FOUNDATION
发明人:
Robert A. Galemmo, Jr.,Andrew B. West,Joseph A. Maddry,Subramaniam Ananthan,Ashish Kumar Pathak,Jacob Valiyaveettil
申请号：
US13875751
公开号：
US09187484B2
申请日:
2013.05.02
申请国别(地区):
US
年份:
2015
代理人:
摘要：
Provided are novel LRRK2 kinase inhibitors and methods of treating disease states using these inhibitors. Examples of LRRK2 kinase inhibitors are compounds of the formula:or derivatives thereof. An example is 1-(piperidin-1-yl)-2-((3-(thiophen-2-yl)-[1,2,4]triazolo[4,3-b]pyridazin-6-yl)thio)butan-1-one. Particular uses include treating neurodegenerative diseases, cancer, autoimmune diseases and leprosy.
