A method for preventing and/or treating coronary atherosclerosis and related diseases thereof of a subject, comprising administering a preventively and/or therapeutically effective amount of plasminogen to a subject suffering, suspected to suffer, or at the risk of suffering coronary atherosclerosis and related diseases thereof. Also provided are a medicine, pharmaceutical composition, product, and kit comprising plasminogen and used for preventing and/or treating coronary atherosclerosis and related diseases thereof of a subject.本發明涉及一種用於預防和/或治療受試者冠狀動脈粥樣硬化及其相關病症的方法,包括給藥受試者預防和/或治療有效量的纖溶酶原,其中所述受試者患有、懷疑患有冠狀動脈粥樣硬化及其相關病症或具有患上冠狀動脈粥樣硬化及其相關病症的風險。本發明還涉及用於預防和/或治療受試者冠狀動脈粥樣硬化及其相關病症的包含纖溶酶原的藥物、藥物組合物、製品、試劑盒。