A method for preventing and/or treating coronary atherosclerosis and related diseases thereof of a subject, comprising administering a preventively and/or therapeutically effective amount of plasminogen to a subject suffering, suspected to suffer, or at the risk of suffering coronary atherosclerosis and related diseases thereof. Also provided are a medicine, pharmaceutical composition, product, and kit comprising plasminogen and used for preventing and/or treating coronary atherosclerosis and related diseases thereof of a subject.
