Bradner, James,Moellering, Raymond,Verdine, Gregory L.
申请号：
AU2014200485
公开号：
AU2014200485A1
申请日:
2014.01.30
申请国别(地区):
AU
年份:
2014
代理人:
摘要：
#$%^&*AU2014200485A120140220.pdf#####ABSTRACT Stably cross-linked a polypeptides related to human MAML are described. These cross-linked polypeptides contain at least two modified amino acids that together form an internal cross-link or tether that can help to stabilize the alpha-helical secondary structure that is thought to be important for binding of MAML peptides to the Notch transcription complex, a complex that includes ICN and CSL.
