James Bradner,Raymond Moellering,Gregory L. Verdine
申请号：
US12478504
公开号：
US09074009B2
申请日:
2009.06.04
申请国别(地区):
US
年份:
2015
代理人:
摘要：
Stably cross-linked a polypeptides related to human MAML are described. These cross-linked polypeptides contain at least two modified amino acids that together form an internal cross-link or tether that can help to stabilize the alpha-helical secondary structure that is thought to be important for binding of MAML peptides to the Notch transcription complex, a complex that includes ICN and CSL.
