Stabilized MAML peptides and uses thereof

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专利权人:

发明人:

申请号：

EP12158552.5

公开号：

EP2489360A1

申请日:

2007.11.15

申请国别(地区):

EP

年份:

2012

代理人:

摘要：

Stably cross-linked a polypeptides related to human MAML are described. These cross-linked polypeptides contain at least two modified amino acids that together form an internal cross-link or tether that can help to stabilize the alpha-helical secondary structure that is thought to be important for binding of MAML peptides to the Notch transcription complex, a complex that includes ICN and CSL.

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