Vadim Kraynov,Nick Knudsen,Ahma Hewet,Kristine De Dios,Jason Pinkstaff,Lorraine Sullivan
申请号：
US13212101
公开号：
US08691940B2
申请日:
2011.08.17
申请国别(地区):
US
年份:
2014
代理人:
摘要：
Modified relaxin polypeptides and their uses are provided. In one aspect, the disclosure provides a relaxin polypeptide comprising one or more non-naturally encoded amino acids. The polypeptide may be linked to a linker, polymer, or biologically active molecule. The serum half-life of the relaxin polypeptide may be enhanced relative to the unconjugated form. In another aspect, the disclosure provides methods of treating a patient having a disorder modulated by relaxin.
