Marco Gil;Filipe Gaspar;Constanca Cacela;Ricardo Mendonca
发明人:
Marco Gil,Constanca Cacela,Ricardo Mendonca,Filipe Gaspar
申请号：
US13642397
公开号：
US20130203717A1
申请日:
2011.04.21
申请国别(地区):
US
年份:
2013
代理人:
摘要：
A process for reducing the particle size of an active pharmaceutical ingredient (API) while maintaining its polymorphic form, comprises the step of processing the active pharmaceutical ingredient by cavitation at elevated pressure. The process preferably comprises the step of isolating the processed active ingredient in the form of powder, wherein the isolation step comprises filtration or spray drying. Particles produced by the process of the invention typically have a span value of less than 2.5.
