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Patch and method for producing the same
专利权人:
Hisamitsu Pharmaceutical Co.; Inc.
发明人:
Kazunosuke Aida,Terumitsu Kaiho,Tetsurou Tateishi,Nobuo Tsutsumi
申请号:
US13923828
公开号:
US08877235B2
申请日:
2013.06.21
申请国别(地区):
US
年份:
2014
代理人:
摘要:
A method for producing a patch comprising a support layer and an adhesive agent layer arranged on at least one surface of the support layer, the method comprising:a step A of obtaining an adhesive agent layer composition comprising oxybutynin hydrochloride as a drug, an acrylic-based polymer and/or a rubber-based polymer as an adhesive base agent, liquid paraffin, a sterol, an organic acid, and a tackifier;a step B of heating the adhesive agent layer composition at a temperature in a range from 55 to 70° C. for 1 to 24 hours; anda step C of cooling the heated adhesive agent layer composition to a temperature lower than room temperature at an average rate of temperature drop of 1 to 20° C./hour, thereby obtaining the adhesive agent layer comprising the drug at a supersaturated concentration in a dissolved form.
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