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Method for producing patch, patch and package
专利权人:
HISAMITSU PHARMACEUTICAL CO.; INC.
发明人:
Takahito Yoshizaki,Kouji Tanaka,Kazunosuke Aida,Terumitsu Kaiho,Nobuo Tsutsumi
申请号:
US14317976
公开号:
US09320728B2
申请日:
2014.06.27
申请国别(地区):
US
年份:
2016
代理人:
摘要:
A method for producing a patch comprising a support layer and an adhesive agent layer arranged on at least one surface of the support layer, the method comprising:step A) obtaining an adhesive agent layer composition comprising free ropinirole in an amount which results in a content of 5 to 13.2% by mass in an obtained adhesive agent layer;step B) heating the adhesive agent layer composition at a temperature in a range from 50 to 76° C. for 5 minutes to 24 hours; andstep C) cooling the heated adhesive agent layer composition to normal temperature at an average rate of temperature drop of 1 to 20° C./hour, thereby obtaining the adhesive agent layer comprising the free ropinirole at a supersaturated concentration in a dissolved form.
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中国工程科技知识中心
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